Objective To point out the design problem of “Interaction Design for Human-in-the-Loop Hybrid Intelligence (HILI)”, and to study the interaction design in HILI systems, so as to provide an index and reference for related design, technology and application research. Methods Starting from the concept and architecture of human-in-the-loop hybrid intelligence, the interaction design of human-in-the-loop hybrid intelligence is introduced; based on the collation of related literature, the common interface components and interaction methods are summarized; and the life cycle of human-in-the-loop hybrid intelligence is summarized. Conclusion: It is shown that human-in-the-loop hybrid intelligence is an intelligence model that requires user interaction; the system architecture consisting of users, artificial intelligence algorithms, and user interfaces is introduced; the possible interaction modes of existing work for different data types are summarized; the design challenges during the complete life cycle of human-in-the-loop hybrid intelligence are analyzed; key interface components are extracted based on the existing literature; design suggestions for human-in-the-loop hybrid intelligence systems are proposed; the design of human-in-the-loop hybrid intelligence systems from the perspective of intelligence are proposed; and the design of human-in-the-loop hybrid intelligence systems from the perspective of intelligence are summarized. We analyze the design challenges in the complete lifecycle of human-in-the-loop hybrid intelligence, extract the key interface components based on the existing literature, and propose the design of human-in-the-loop hybrid intelligence systems. We also propose to establish a design methodology and improve the design tools from the aspects of intelligent systems, users, and designers, so as to support and promote the application of human-in-the-loop hybrid intelligence systems more effectively.